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Uric Acid as a predictor of adverse maternal and perinatal outcomes in women hospitalized with preeclampsia.

TitleUric Acid as a predictor of adverse maternal and perinatal outcomes in women hospitalized with preeclampsia.
Publication TypeJournal Article
Year of Publication2014
AuthorsLivingston, J, Payne, BA, Brown, M, Roberts, J, Côté, A-M, Magee, LA, von Dadelszen, P
Corporate AuthorsPIERS Study Group
JournalJ Obstet Gynaecol Can
Volume36
Issue10
Pagination870-877
Date Published2014 Oct
ISSN1701-2163
KeywordsAdult, Cohort Studies, Female, Humans, PIERS, Pre-Eclampsia, Predictive Value of Tests, Pregnancy, Pregnancy Outcome, Risk Factors, Uric Acid
Abstract

OBJECTIVE: Elevated serum uric acid is commonly observed in women with preeclampsia, but its utility in predicting adverse outcomes has recently been disputed. Our goal was to analyze data from a large cohort of women with preeclampsia to determine the utility of serum uric acid in predicting adverse maternal and perinatal outcomes.

METHODS: Data were obtained from an ongoing international prospective study of women admitted to hospital with preeclampsia (Pre-eclampsia Integrated Estimate of RiSk). Univariate logistic regression was used to determine the relationship between serum uric acid concentration (both absolute and gestational-age corrected [Z score]) and adverse outcomes (maternal and perinatal). Analyses were conducted to compare cohorts of women with preeclampsia as defined by hypertension and proteinuria versus hypertension and hyperuricemia.

RESULTS: Uric acid Z score was associated with adverse perinatal outcome (OR 1.5; 95% CI 1.4 to 1.7) and had a point estimate > 0.7 (area under the curve receiver operating characteristic 0.72; 95% CI 0.69 to 0.74). Serum uric acid concentration also showed a significant association with adverse maternal outcomes, but the point estimate was < 0.7. No significant differences were observed between groups in which preeclampsia was defined by hypertension and proteinuria and by hypertension and hyperuricemia.

CONCLUSION: In women admitted to hospital with preeclampsia, the serum uric acid concentration, corrected for gestational age via a Z score, is clinically useful in predicting adverse perinatal outcomes but not maternal outcomes.

DOI10.1016/S1701-2163(15)30435-7
Alternate JournalJ Obstet Gynaecol Can
Citation Key485
PubMed ID25375299
Grant List / / Canadian Institutes of Health Research / Canada