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Syncytiotrophoblast extracellular vesicles - Circulating biopsies reflecting placental health.

TitleSyncytiotrophoblast extracellular vesicles - Circulating biopsies reflecting placental health.
Publication TypeJournal Article
Year of Publication2017
AuthorsTannetta, D, Collett, G, Vatish, M, Redman, C, Sargent, I
Date Published2017 04
KeywordsBiopsy, COLAB, Extracellular Vesicles, Female, Global Pregnancy Collaboration (CoLab), Health Status, Humans, Placenta, Pregnancy, Trophoblasts

The ability to directly monitor the status of the placenta throughout pregnancy would be a major advance in both general and personalized obstetric care, allowing treatments to be tailored to the dynamic changes that can occur in gestation. Syncytiotrophoblast extracellular vesicles (STBEV) are membrane bound vesicles, released from the surface of the placenta directly into the maternal circulation, in the form of exosomes, microvesicles and apoptotic bodies. They carry many syncytiotrophoblast derived factors such as proteins, lipids, glycans and nucleic acids, which together could dynamically signal to the mother the status of the placenta. We review STBEV research and discuss the potential for STBEV to be used as circulating syncytiotrophoblast biopsies, accessible via a simple blood sample throughout pregnancy, giving a real-time readout of syncytiotrophoblast health. We also highlight advances in the use of extracellular vesicles as circulating tumour derived biopsies in the field of cancer research, which could prove beneficial to obstetric care.

Alternate JournalPlacenta
Citation Key574
PubMed ID27899180
PubMed Central IDPMC5423500
Grant ListMR/J003360/1 / / Medical Research Council / United Kingdom
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