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Random urine albumin:creatinine ratio in high-risk pregnancy - Is it clinically useful?

TitleRandom urine albumin:creatinine ratio in high-risk pregnancy - Is it clinically useful?
Publication TypeJournal Article
Year of Publication2013
AuthorsDe Silva, D, Halstead, A, Côté, A-M, Sabr, Y, von Dadelszen, P, Magee, LA
JournalPregnancy Hypertens
Volume3
Issue2
Pagination112-4
Date Published2013 Apr
ISSN2210-7789
KeywordsPIERS
Abstract

We evaluated the frequency of measurable albuminuria (⩾6.00mg/L) for albumin:creatinine ratios (ACr) among 160 consecutive women attending high-risk clinics. Of last urine samples before delivery, 76 had measurable albuminuria and 41/76 (53.9%) had ACr ⩾2mg/mmol of which 7.3% had normal pregnancy outcome. 84 samples had albuminuria <6.00mg/L and 43/84 (51.2%) had ACr ⩾2mg/mmol of which 25.6% had normal pregnancy outcome (p=0.025). Excluding 48/160 (30.0%) dilute samples (urinary creatinine <3mM), no samples with unmeasurable albuminuria had ACr ⩾2mg/mmol. In pregnancy, urine is often dilute and without measurable albuminuria, leading to a clinically relevant proportion of false positive results by ACr.

DOI10.1016/j.preghy.2013.02.001
Alternate JournalPregnancy Hypertens
Citation Key480
PubMed ID26105946