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Microchimerism: Defining and redefining the prepregnancy context - A review.

TitleMicrochimerism: Defining and redefining the prepregnancy context - A review.
Publication TypeJournal Article
Year of Publication2017
AuthorsGammill, H, Harrington, W
Date Published2017 Dec
KeywordsChimerism, COLAB, Female, Fetus, Global Pregnancy Collaboration (CoLab), Humans, Malaria, Maternal-Fetal Exchange, Placenta Diseases, Pregnancy

Bidirectional transplacental exchange characterizes human pregnancy. Cells exchanged between mother and fetus can durably persist as microchimerism and may have both short- and long-term consequences for the recipient. The amount, type, and persistence of microchimerism are influenced by obstetric characteristics, pregnancy complications, exposures to infection, and other factors. A reproductive-aged woman enters pregnancy harboring previously acquired microchimeric "grafts," which may influence her preconception health and her subsequent pregnancy outcomes. Many questions remain to be answered about microchimerism with broad-ranging implications. This review will summarize key aspects of this field of research and propose important questions to be addressed moving forward.

Alternate JournalPlacenta
Citation Key564
PubMed ID28911790
PubMed Central IDPMC5718967
Grant ListK08 HD067221 / HD / NICHD NIH HHS / United States
T32 HD007233 / HD / NICHD NIH HHS / United States