CLIP (Community-Level Interventions for Pre-eclampsia)


Community Level Interventions for Pre-eclampsia (CLIP) cluster randomised controlled trials (cRCTs) were conducted from Feb 2014- Feb 2017 in Karnataka, India (cRCT, 12 clusters), Sindh, Pakistan (cRCT, 20 clusters), Maputo and Gaza provinces, Mozambique (cRCTs, 12 clusters) and in Nigeria as an implementation study (5 clusters).

The aim of the CLIP Trials (NCT01911494), was to reduce the burden of deaths and illness in mothers and babies through community-level education, case identification, monitoring, and treatment of pregnancy hypertension.


The CLIP Trials package included community engagement, regular monitoring of pregnancies by community health care providers, community level treatment with magnesium sulphate and oral methyldopa and recommendation for referral to higher level health facilities for identified high risk women.


  • These results offer a critical window into understanding the effectiveness of community-based interventions for addressing maternal and perinatal outcomes in three different geographies at varying stages of development in sub Saharan Africa and South Asia.
  • The CLIP results offer community-ascertained and physician-reviewed population level rates of maternal and neonatal morbidities.
  • Using data from blood pressure measured in women’s homes, we have been able to ascertain community rates of pregnancy hypertension.

If you are interested in learning more about our CLIP projects, you can find the primary papers here:

CLIP Mozambique

CLIP India

CLIP Pakistan: