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The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study.

TitleThe effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study.
Publication TypeJournal Article
Year of Publication2015
AuthorsHofmeyr, J, Seuc, A, Betrán, A, Purnat, T, Ciganda, A, Munjanja, S, Manyame, S, Singata-Madliki, M, Fawcus, S, Frank, K, Hall, D, Cormick, G, Roberts, J, Bergel, E, Drebit, S, von Dadelszen, P, Belizan, J
Corporate AuthorsCalcium and Pre-eclampsia Study Group
JournalPregnancy Hypertens
Volume5
Issue4
Pagination273-9
Date Published2015 Oct
ISSN2210-7797
KeywordsAdult, Argentina, Blood Pressure, Blood Pressure Determination, Bone Density Conservation Agents, Calcium, Dietary, CAP, Double-Blind Method, Female, Humans, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Cardiovascular, Risk Assessment, South Africa, Treatment Outcome, World Health Organization, Zimbabwe
Abstract

BACKGROUND: Epidemiological findings suggest that the link between poverty and pre-eclampsia might be dietary calcium deficiency. Calcium supplementation has been associated with a modest reduction in pre-eclampsia, and also in blood pressure (BP).

METHODS: This exploratory sub-study of the WHO Calcium and Pre-eclampsia (CAP) trial aims to determine the effect of 500mg/day elemental calcium on the blood pressure of non-pregnant women with previous pre-eclampsia. Non-pregnant women with at least one subsequent follow-up trial visit at approximately 12 or 24weeks after randomization were included.

RESULTS: Of 836 women randomized by 9 September 2014, 1st visit data were available in 367 women of whom 217 had previously had severe pre-eclampsia, 2nd visit data were available in 201 women. There was an overall trend to reduced BP in the calcium supplementation group (1-2.5mmHg) although differences were small and not statistically significant. In the subgroup with previous severe pre-eclampsia, the mean diastolic BP change in the calcium group (-2.6mmHg) was statistically larger than in the placebo group (+0.8mmHg), (mean difference -3.4, 95% CI -0.4 to -6.4; p=0.025). The effect of calcium on diastolic BP at 12weeks was greater than in those with non-severe pre-eclampsia (p=0.020, ANOVA analysis).

CONCLUSIONS: There is an overall trend to reduced BP but only statistically significant in the diastolic BP of women with previous severe pre-eclampsia. This is consistent with our hypothesis that this group is more sensitive to calcium supplementation, however results need to be interpreted with caution.

DOI10.1016/j.preghy.2015.04.001
Alternate JournalPregnancy Hypertens
Citation Key452
PubMed ID26597740
Grant List001 / / World Health Organization / International