| Title | Early administration of low-dose aspirin for the prevention of severe and mild preeclampsia: a systematic review and meta-analysis. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Roberge, S, Giguère, Y, Villa, P, Nicolaides, K, Vainio, M, Forest, J-C, von Dadelszen, P, von Dadelszen, P, Vaiman, D, Tapp, S, Bujold, E |
| Journal | Am J Perinatol |
| Volume | 29 |
| Issue | 7 |
| Pagination | 551-6 |
| Date Published | 2012 Aug |
| ISSN | 1098-8785 |
| Keywords | Aspirin, Female, Humans, Platelet Aggregation Inhibitors, Pre-Eclampsia, Pregnancy, Severity of Illness Index |
| Abstract | OBJECTIVE: To determine whether early administration of aspirin prevents severe and mild preeclampsia. STUDY DESIGN: A systematic review and meta-analysis of randomized controlled trials were performed. Studies in which women were randomized at or before 16 weeks' gestation to low-dose aspirin versus placebo or no treatment were included. The outcomes of interest were severe preeclampsia and mild preeclampsia. Pooled relative risks with their 95% confidence intervals (CIs) were calculated. RESULTS: Among 7941 citations retrieved, 352 were completely reviewed and four studies (392 women) fulfilled the inclusion criteria and were analyzed. When compared with controls, aspirin started at ≤16 weeks was associated with a significant reduction in severe (relative risk: 0.22, 95% CI: 0.08 to 0.57) but not mild (relative risk: 0.81, 95% CI: 0.33 to 1.96) preeclampsia. CONCLUSION: Low-dose aspirin initiated at or before 16 weeks reduces the risk of severe preeclampsia, but not mild preeclampsia. |
| DOI | 10.1055/s-0032-1310527 |
| Alternate Journal | Am J Perinatol |
| Citation Key | 611 |
| PubMed ID | 22495898 |
