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Early administration of low-dose aspirin for the prevention of severe and mild preeclampsia: a systematic review and meta-analysis.

TitleEarly administration of low-dose aspirin for the prevention of severe and mild preeclampsia: a systematic review and meta-analysis.
Publication TypeJournal Article
Year of Publication2012
AuthorsRoberge, S, Giguère, Y, Villa, P, Nicolaides, K, Vainio, M, Forest, J-C, von Dadelszen, P, von Dadelszen, P, Vaiman, D, Tapp, S, Bujold, E
JournalAm J Perinatol
Volume29
Issue7
Pagination551-6
Date Published2012 Aug
ISSN1098-8785
KeywordsAspirin, Female, Humans, Platelet Aggregation Inhibitors, Pre-Eclampsia, Pregnancy, Severity of Illness Index
Abstract

OBJECTIVE: To determine whether early administration of aspirin prevents severe and mild preeclampsia.

STUDY DESIGN: A systematic review and meta-analysis of randomized controlled trials were performed. Studies in which women were randomized at or before 16 weeks' gestation to low-dose aspirin versus placebo or no treatment were included. The outcomes of interest were severe preeclampsia and mild preeclampsia. Pooled relative risks with their 95% confidence intervals (CIs) were calculated.

RESULTS: Among 7941 citations retrieved, 352 were completely reviewed and four studies (392 women) fulfilled the inclusion criteria and were analyzed. When compared with controls, aspirin started at ≤16 weeks was associated with a significant reduction in severe (relative risk: 0.22, 95% CI: 0.08 to 0.57) but not mild (relative risk: 0.81, 95% CI: 0.33 to 1.96) preeclampsia.

CONCLUSION: Low-dose aspirin initiated at or before 16 weeks reduces the risk of severe preeclampsia, but not mild preeclampsia.

DOI10.1055/s-0032-1310527
Alternate JournalAm J Perinatol
Citation Key611
PubMed ID22495898